Lessons Learned from Synovial Tissue Analysis
نویسنده
چکیده
Because many inflammatory arthropathies primarily involve the synovial tissue, there has been increased interest in investigations of the pathologic changes in synovial biopsy specimens during the last 2 decades (Reviewed in [1]). This development has been stimulated by technical advances such as the advent of new methods to obtain synovial tissue specimens from actively inflamed joints and clinically quiescent joints under local anesthesia, such as mini-arthroscopy and ultrasound-guided synovial biopsy, and because of the development of new laboratory techniques used to analyse the synovial tissue samples. Systematic analysis of synovial tissue has lead to the identification of key therapeutic targets, such as TNF and IL6 as well as many others that are currently being tested.
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